2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics [2023 ICCP450/JSSX]

Program

Timetable

Timetable

General Session

Poster Presentation

Poster Presentation
[Late-breaking Abstracts]

Plenary lecture 1 (co-sponsored by Annual meeting and Short course)

September 25 (Mon.) 18:00-19:00  Room A (1F Medium Hall - Earth)

• ChairKiyomi Ito
• Research Institute of Pharmaceutical Sciences, Musashino University

An improved approach to P450 reaction phenotyping

• SpeakerR. Scott Obach
• Groton Laboratories, Pfizer Inc.

Plenary lecture 2

September 28 (Thu.) 13:45-14:45  Room A (1F Medium Hall - Earth)

• ChairKouichi Yoshinari
• School of Pharmaceutical Sciences, University of Shizuoka

Bile Acid Generating-Cytochrome P450 8B1: Structure/Function Towards Drug Design

• SpeakerEmily E. Scott
• Departments of Medicinal Chemistry and Pharmacology, University of Michigan

Plenary lecture 3

September 29 (Fri.) 11:15-12:15  Room A (1F Medium Hall - Earth)

• ChairShingo Nagano
• Graduate School of Engineering, Tottori University

Using Decoy Molecules to Manipulate Cytochrome P450BM3 Biotransformations

• SpeakerOsami Shoji
• Department of Chemistry, Graduate School of Science, Nagoya University

New JSSX President's Lecture

September 28 (Thu.) 15:20-15:40 Room C (6F Reception Hall)

• ChairFumiyoshi Yamashita
• Graduate School of Pharmaceutical Sciences, Kyoto University

Message from the new president

• SpeakerYukio Kato
• Laboratory of Molecular Pharmacotherapeutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University

Plenary symposium

September 26 (Tue.) 16:00-18:30  Room A (1F Medium Hall - Earth)

• ChairsMasahiko Negishi
• National Institute of Environmental Health Sciences, National Institutes of Health
•  Yasushi Yamazoe
• Tohoku University

Remembering Tsuneo Omura: A beloved mentor and a leader in cytochrome P450 and biochemistry

• PS1-1Kinetics and Mechanisms of Complex P-450 Catalyzed Steroid Oxidations
• SpeakerF. Peter Guengerich
• Department of Biochemistry, Vanderbilt University School of Medicine
• PS1-2Steroidogenic Cytochromes P450 and Beyond
• SpeakerBon-Chu Chung
• China Medical University, National Laboratory Animal Center National Applied Research Laboratories, Academia Sinica
• PS1-3About a marathon in P450 pharmacogenetics
• SpeakerUlrich M. Zanger
• Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
• PS1-4Ancestral and extant steroid hydroxylases
• SpeakerRita Ruth Bernhardt
• Saarland University Saarbruecken, Germany
• PS1-5Is Ad4BP almighty?
• SpeakerKen-ichirou Morohashi
• Graduate School of Medicine, Kurume University

Symposium 1

September 26 (Tue.) 9:00-11:00  Room A (1F Medium Hall - Earth)

Use and regulation of biomarkers in drug development

• ChairsAkihiro Ishiguro
• Pharmaceuticals and Medical Devices Agency
•  Kosuke Saito
• Division of Medical Safety Science, National Institute of Health Sciences

• S01-1Overview of biomarkers as drug development tools
• SpeakerKosuke Saito
• Division of Medical Safety Science, National Institute of Health Sciences
• S01-2Recent insights and advances in assessing drug interaction risk using endogenous substrates of drug transporters
• SpeakerHiroyuki Kusuhara
• Graduate School of Pharmaceutical Sciences, The University of Tokyo
• S01-3Evaluation of OATP1B Inhibitory Potential Using an Endogenous Biomarker, Coproporphyrin-I in New Drug Application of Ensitrelvir (Xocova^®) as an Oral Anti-SARS-CoV-2 Agent
• SpeakerRyosuke Watari
• Laboratory for Drug Discovery and Development, Shionogi & CO., LTD.
• S01-4PMDA initiatives to promote utilization of biomarkers in drug development
• SpeakerAkihiro Ishiguro
• Pharmaceuticals and Medical Devices Agency
• S01-5Analytical method development and validation for nucleic acid biomarkers as a drug development tool: points to consider
• SpeakerYuchen Sun
• Division of Medicinal Safety Science, National Institute of Health Sciences

Symposium 2

September 26 (Tue.) 9:00-11:00  Room B (11F Conference Hall - Winds)

Drug oxidation and metabolism in pharmacology/toxicology

• ChairHiroshi Yamazaki
• Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• S02-1Model Selection for Drug Oxygenations Mediated by Polymorphic Human Enzymes
• SpeakerHiroshi Yamazaki
• Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
• S02-2Hydroxylation and lyase reactions of steroids catalyzed by human and mouse cytochromes P450 17A1
• SpeakerDonghak Kim
• Konkuk University
• S02-3Drug interactions with Shengmai-san and Xin-yi-san herbal formulas: mechanisms, ingredients, and pharmacokinetics
• SpeakerYune-Fang Ueng
• Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Taipei, Taiwan / Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
• S02-4Static and physiologically based pharmacokinetic modeling to assess the risk of drug-drug interactions arising from inhibition of morphine glucuronidation
• SpeakerVerawan Uchaipichat
• Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen
• S02-5Identification and characterisation of a novel amino acid conjugate; ergothioneine conjugate of raloxifene through in vitro and in vivo studies
• SpeakerT. Thanga Mariappan
• Scientific Director, Bristol Myers Squibb, India

Symposium 3

September 26 (Tue.) 9:00-11:00  Room C (6F Reception Hall)

DDS Development Strategies for the Creation of Innovative Drugs

• ChairsShigeru Kawakami
• Graduate School of Biomedical Sciences, Nagasaki University
•  Tatsuhiro Ishida
• Institute of Biomedical Sciences, Tokushima University

• S03-1Pharmacokinetic PET study of new modalities and theranostics
• SpeakerHidefumi Mukai
• Graduate School of Biomedical Sciences, Nagasaki University
• S03-2Controlling tissue distribution of oligonucleotide therapeutics by structural optimization
• SpeakerMakiya Nishikawa
• Faculty of Pharmaceutical Sciences, Tokyo University of Science
• S03-3Preparation of hepatic cancer spheroids using bacterial nano-cellulose and evaluation of its drug-metabolism activity for accelerating drug discovery
• SpeakerHidenori Ando
• Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University
• S03-4Development of skeletal muscle microphysiological systems
• SpeakerKazunori Shimizu
• Graduate School of Engineering, Nagoya University
• S03-5Re-thinking of delivery strategy of biologics and nano DDS to tumor: beyond the EPR effect
• SpeakerHiroto Hatakeyama
• Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University

Symposium 4

September 26 (Tue.) 9:00-11:00  Room D (10F Conference Room 1001-1&2)

Sustainability, biomarker, and bioremediation: The role of cytochrome P450

• ChairsHirofumi Ichinose
• Faculty of Agriculture, Kyushu University
•  Mayumi Ishizuka
• Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University

• S04-1In vitro and in silico assessments of chemical-induced disruption of nuclear receptor-cytochrome P450 signaling pathways in aquatic mammals
• SpeakerHisato Iwata
• Center for Marine Environmental Studies, Ehime University
• S04-2Metabolic mechanisms of persistent environmental pollutants by mammalian cytochrome P450 monooxygenases
• SpeakerHideyuki Inui
• Biosignal Research Center, Kobe University
• S04-3Synergy between Experiments and Computations: A Green Channel for Revealing Uncommon Metabolic Mechanism of Xenobiotics by P450 Enzymes
• SpeakerLi Ji
• School of Environment Science and Spatial Informatics, China University of Mining and Technology
• S04-4Engineering P450 systems for sustainable fine chemical synthesis in microalgae
• SpeakerElizabeth M.J. Gillam
• School of Chemistry & Molecular Biosciences, The University of Queensland Brisbane AUSTRALIA

Symposium 5

September 26 (Tue.) 9:00-11:00  Room E (9F Conference Room 910)

Phase II conjugation reactions involved in the regulation of biologically active molecules

• ChairsSin'ichi Ikushiro
• Toyama Prefectural University
•  Katsuhisa Kurogi
• University of Miyazaki

• S05-1Impact of genetic polymorphisms on drug metabolism by Phase II cytosolic sulfotransferases (SULTs)
• SpeakerMing-Cheh Liu
• University of Toledo
• S05-2Investigation of antioxidant activities of Phase-II sulfated compounds
• SpeakerShin Yasuda
• University of Tokai
• S05-3Evolution of phase II xenobiotic metabolism enzymes in mammalians
• SpeakerMitsuki Kondo
• National Institute for Environmental Studies
• S05-4Physiological roles of conjugates in functional expression of orally -administrated compounds
• SpeakerMiyu Nishikawa
• Toyama Prefectural University

Symposium 6

September 26 (Tue.) 13:45~15:45  Room A (1F Medium Hall - Earth)

Current trends in establishment and implementation of new regulatory guidelines related to pharmacokinetics

• ChairsAkiko Ishii-Watabe
• Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
•  Naomi Nagai
• Research Institute of Pharmaceutical Sciences, Musashino University

• S06-1International Harmonisation of “Bioanalytical Method Validation and Study Sample Analysis” by establishment of ICH M10
• SpeakerAkiko Ishii-Watabe
• Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
• S06-2Industry Perspectives on the ICH M10 Implementation
• SpeakerMasayo Hashimoto
• Sumitomo Pharma Co., Ltd.
• S06-3Leveraging patient-centric sampling for clinical drug development and decentralized clinical trials
• SpeakerMototsugu Ito
• Astellas Pharma Inc.
• S06-4ICH M13A: Draft Guideline of Bioequivalence for Immediate-Release Solid Oral Dosage Forms: Comparison with Japanese Bioequivalence guideline
• SpeakerRyosuke Kuribayashi
• Pharmaceuticals and Medical Devices Agency
• S06-5ICH M13: Bioequivalence for Immediate-Release Solid Oral Dosage Forms -From Industry perspective-
• SpeakerTsuyoshi Kobayashi
• Japan Pharmaceutical Manufacturers Association (JPMA)

Symposium 7

September 26 (Tue.) 13:45~15:45  Room B (11F Conference Hall - Winds)

Frontline Research for Membrane Proteins and Enzymes for Human Diseases

• ChairsTakeo Nakanishi
• Graduate School of Pharmacy, Takasaki University of Health and Welfare
•  Sunhapas Soodvilai
• Department of Physiology, Faculty of Science, Mahidol University

• S07-1Pharmacological effects of natural products on chloride channel: Therapeutic application for treatment of polycystic kidney disease
• SpeakerSunhapas Soodvilai
• Department of Physiology, Faculty of Science, Mahidol University
• S07-2Involvement of Organic Cation Transporter OCTN1/SLC22A4 in Neurogenesis: a Potential Preventive Target for Neurodegenerative Diseases
• SpeakerTakahiro Ishimoto
• Laboratory of Molecular Pharmacotherapeutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
• S07-3Nicotine addiction and dopamine D₃ receptor
• SpeakerKyeong-Man Kim
• Pharmacology Laboratory, College of Pharmacy, Chonnam National University
• S07-4Drug transporters and metabolic enzymes mediate chemotherapy resistance and drug resistance reversal
• SpeakerLushan Yu
• College of Pharmaceutical Sciences, Zhejiang University
• S07-5Analysis of Membrane Transporters in Fatty Liver Using NAFLD Models
• SpeakerTakeo Nakanishi
• Graduate School of Pharmacy, Takasaki University of Health and Welfare

Symposium 8

September 26 (Tue.) 13:45-15:45  Room C (6F Reception Hall)

Beyond bone health: Development of novel vitamin D derivatives and vitamin D hydroxylases

• ChairsToshiyuki Sakaki
• Faculty of Engineering, Toyama prefectural University
•  Midori Takimoto-Kamimura
• CBI Research Institute Quantum-Structural Life science Laboratories

• S08-1Design and synthesis of CYP24A1-resistant vitamin D₃ analogues for drug development
• SpeakerFumihiro Kawagoe
• Teikyo University Faculty of pharmaceutical sciences
• S08-2Production of useful metabolites using vitamin D hydroxylases from mammals and actinomycetes
• SpeakerKaori Yasuda
• Faculty of Engineering, Toyama prefectural University
• S08-3Characterization of bacterial vitamin D₂ and D₃ hydroxylases from Bacillus megaterium
• SpeakerRita Ruth Bernhardt
• Saarland University Saarbruecken, Germany
• S08-4X-ray structural studies of CYP105A1 and azole-based inhibitor complex
• SpeakerYuu Hirano
• Institute for Quantum Life Science, National Institutes for Quantum Science and Technology

Symposium 9

September 26 (Tue.) 13:45-15:45  Room D (10F Conference Room 1001-1&2)

Biophysical Techniques for P450 Studies

• ChairsMasaki Horitani
• Faculty of Agriculture, Saga University
•  Ilia Denisov
• University of Illinois, Urbana-Champaign

• S09-1Solvent isotope effect as a mechanistic probe in P450 catalysis
• SpeakerIlia Denisov
• University of Illinois, Urbana-Champaign
• S09-2Label-free imaging of cytochrome P450 using Raman microscopy
• SpeakerKatsumasa Fujita
• Department of Applied Physics, Osaka University
• S09-3The combination of EPR spectroscopy and X-ray crystallography revealed that the active site rearrangement of the di-metal center by substrate binding is temperature dependent
• SpeakerMasaki Horitani
• Faculty of Agriculture, Saga University
• S09-4Time-resolved crystallography of ultrafast light-driven DNA repair by photolyases
• SpeakerYoshitaka Bessho
• Graduate School of Agricultural and Life Sciences, The University of Tokyo

Symposium 10

September 26 (Tue.) 13:45-15:45  Room E (9F Conference Room 910)

Animal models to predict drug metabolism and toxicity in human

• ChairsHiroshi Suemizu
• Central Institute for Experimental Animals
•  Kaoru Kobayashi
• Meiji Pharmaceutical University

• S10-1Development of Advanced Liver-Humanized Mice Models
• SpeakerHiroshi Suemizu
• Central Institute for Experimental Animals
• S10-2Chimeric mice with humanized livers using cDNA-uPA/SCID mice
• SpeakerChise Tateno
• R&D Department, PhoenixBio Co., Ltd.
• S10-3Humanized animals via chromosome engineering technology
• SpeakerYasuhiro Kazuki
• Chromosome Engineering Research Center, Tottori University
• S10-4Uptake transporters as determinants of chemotherapy-induced toxicity
• SpeakerShuiying Hu
• Division of Outcomes and Translational Sciences, College of Pharmacy & Comprehensive Cancer Center The Ohio State University

Symposium 11

September 27 (Wed.) 9:00-11:00  Room A (1F Medium Hall - Earth)

Innovations in P450 Engineering: Recent Advances and Future Directions

• ChairsOsami Shoji
• Department of Chemistry, Graduate School of Science, Nagoya University
•  Hidehiko Hirakawa
• Faculty of Life and Environmental Sciences, University of Tsukuba

• S11-1Late-Stage Oxyfunctionalization with engineered P450s
• SpeakerVlada B. Urlacher
• Heinrich-Heine-University Düsseldorf
• S11-2Biotechnological applications based on insights from artificial assembly of cytochrome P450 and redox proteins
• SpeakerHidehiko Hirakawa
• Faculty of Life and Environmental Sciences, University of Tsukuba
• S11-3C-C and C-N bond formation by heme enzymes
• SpeakerThomas M. Makris
• North Carolina State University
• S11-4 Engineering and encapsulating a thermostable P450 fatty acid ω-hydroxylase for the sustainable production of biopolymers
• SpeakerYichi Zhang
• School of Chemistry and Molecular Bioscience, The University of Queensland, Australia
• S11-5Drug fragment diversification via P450-catalysed C-H oxidation
• SpeakerVictoria Barros Metlova
• University of Oxford

Symposium 12

September 27 (Wed.) 9:00-11:00  Room B (11F Conference Hall - Winds)

Case study on human disproportionate metabolite and its prediction

• ChairsSatoshi Yamaori
• Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
•  Daigo Asano
• Daiichi Sankyo Co., Ltd

• S12-1Quantitative prediction of exposure to a human disproportionate metabolite of DS-1971a generated by CYP2C8-mediated primary metabolism
• SpeakerDaigo Asano
• Daiichi Sankyo Co., Ltd
• S12-2Humanized Liver TK-NOG Mouse Models: Advancing Drug Metabolism and Toxicity Studies in Humans
• SpeakerShotaro Uehara
• Liver Engineering Laboratory Department of Applied Research for Laboratory Animals Central Institute for Experimental Animals
• S12-3Mechanism and prediction of human disproportionate metabolites of Shionogi compounds mediated by P450 or non-P450 enzymes
• SpeakerKazutaka Sekiguchi
• Shionogi & Co., Ltd.
• S12-4Pharmacokinetic and toxicokinetic studies of two disproportionate metabolites using humanized chimeric mice and common marmosets
• SpeakerHidetaka Kamimura
• Central Institute for Experimental Animals Department of Applied Research for Laboratory Animals

Symposium 13

September 27 (Wed.) 9:00-11:00  Room C (6F Reception Hall)

DRUG ABSORPTION FROM ZERO: Keys to Successful PBPK Modeling and Simulation of Oral Drug Absorption

• ChairsYoshiyuki Shirasaka
• Faculty of Pharmacy, Kanazawa University
•  Toshimichi Nakamura
• Toxicology & DMPK Development Research Group, Teijin Pharma Limited

• S13-1Physiological Perspective: Establishment and application of PBPK absorption model incorporating gastrointestinal fluid dynamics
• SpeakerYoshiyuki Shirasaka
• Faculty of Pharmacy, Kanazawa University
• S13-2Prediction of oral drug absorption of dosage forms using a physiologically based biopharmaceutics modeling approach
• SpeakerAtsushi Kambayashi
• Tokyo University of Science, Faculty of Pharmaceutical Sciences,Department of Medicinal and Life Sciences
• S13-3Prediction of nonlinear absorption for P-gp substrates in human by simultaneous modeling of in vitro and in vivo data
• SpeakerTatsuki Mochizuki
• Chugai Pharmaceutical Co., Ltd
• S13-4Prediction of intestinal P-gp/BCRP and CYP3A-mediated drug-drug interactions using the newly constructed static and dynamic model
• SpeakerSatoshi Asano
• Toxicology & DMPK Development Research Group, Teijin Pharma Limited

Symposium 14

September 27 (Wed.) 9:00-11:00  Room D (10F Conference Room 1001-1&2)

Breaking down boundaries: Exploring non-P450 oxygenase

• ChairsTakeshi Uchida
• Department of Chemistry, Faculty of Science, Hokkaido University
•  Masakazu Sugishima
• Department of Medical Biochemistry, Kurume University School of Medicine

• S14-1The role of water in the one- or two-electron redox chemistry of Compound I in the catalytic cycle of dye-decolorizing peroxidases
• SpeakerJonathan A. R. Worrall
• School of Life Sciences, University of Essex
• S14-2Methane oxidation by a copper monooxygenase: insights from high-resolution cryogenic electron microscopy structure of particulate methane monooxygenase
• SpeakerWei-Hau Chang
• Institute of Chemistry, Academia Sinica
• S14-3Biochemical and crystallographic studies on the human 2-oxoglutarate dependent dioxygenase aspartate/asparagine-β-hydroxylase
• SpeakerLennart Brewitz
• Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford
• S14-4Structural analysis of NADPH-cytochrome P450 reductase in complex with heme oxygenase reveals how reductase supplies reducing equivalents to mono-oxygenase
• SpeakerMasakazu Sugishima
• Department of Medical Biochemistry, Kurume University School of Medicine

Symposium 15

September 28 (Thu.) 9:00-11:00  Room A (1F Medium Hall - Earth)

Frontiers of drug metabolism/toxicity studies using novel in vitro and in silico evaluation systems

• ChairsKousei Ito
• Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
•  Yoshiteru Kamiyama
• Applied DMPK, Non-Clinical Regulatory Science, Astellas Pharma Inc.

• S15-1Development of a toxicity risk assessment system that considers the effects of nonparenchymal cells
• SpeakerRyuji Kato
• Departmant of Pharmacotherapy and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University
• S15-2Optimization of cell-based hepatotoxicity evaluation systems considering drug metabolism
• SpeakerAkinori Takemura
• Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
• S15-3Risk assessment of drug-induced intestinal toxicity with the use of human/animal crypt-derived intestinal cells
• SpeakerKazuya Maeda
• Laboratory of Pharmaceutics, School of Pharmacy, Kitasato University
• S15-4Construction of fused grid-based CYP2C-Template systems and their applications
• SpeakerYoshiya Yamamura
• Applied DMPK, Non-Clinical Regulatory Science, Applied Research & Operations, Astellas Pharma Inc.

Symposium 16

September 28 (Thu.) 9:00-11:00  Room B (11F Conference Hall - Winds)

Structure and Chemistry of the P450 System

• ChairsShingo Nagano
• Graduate School of Engineering, Tottori University
•  Emily E. Scott
• Departments of Medicinal Chemistry and Pharmacology, University of Michigan

• S16-1Structural basis for new chemistry of several microbial P450 enzymes
• SpeakerShengying Li
• State Key Laboratory of Microbial Technology Shandong University
• S16-2The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis
• SpeakerAndrew J. Devine
• School of Chemistry, University of Bristol
• S16-3Novel conformation and mechanism of a cytochrome P450 involved in isoflavone biosynthesis
• SpeakerXiaoqiang Wang
• Department of Biological Science, University of North Texas
• S16-4Structural study of cytochrome P450BM3 catalyzing a non-natural substrate using X-ray free electron laser
• SpeakerSatoshi Nagao
• University of Hyogo / Japan Synchrotron Radiation Research Institute

Symposium 17

September 28 (Thu.) 9:00-11:00  Room C (6F Reception Hall)

Single-cell analytical techniques to visualize detailed pharmacokinetics

• ChairsHideo Takakusa
• Drug Metabolism ＆ Pharmacokinetics Research Labs, Daiichi-Sankyo Co., Ltd.
•  Kosuke Saito
• Division of Medical Safety Science, National Institute of Health Sciences

• S17-1Live Single-cell Mass Spectrometry for Organelle Metabolomics
• SpeakerHajime Mizuno
• Faculty of Pharmacy, Meijo University
• S17-2Comprehensive analyses of intracellular disposition of Fab-siRNA conjugate to identify key issues to improve its RNAi activity
• SpeakerAsami Toshima
• Pharmacokinetics Research Laboratories, Translational Research Unit, R&D Division, Kyowa Kirin Co., Ltd.
• S17-3Development of single-cell multi-omics analytical system using nano-LC/MS
• SpeakerYoshihiro Izumi
• Medical Institute of Bioregulation, Kyushu University
• S17-4Development of microphysiological systems with a perfusable vascular network and the in situ sensing using probe-type devices
• SpeakerYuji Nashimoto
• Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
• S17-5Establishment of a workflow for spatial pharmacokinetics analysis using three-dimensional microscopic imaging data
• SpeakerSiyu Liu
• Takeda Pharmaceutical Company Limited
• S17-6Effect of protein binding on the cellular uptake and antisense activity of cholesterol-conjugated DNA/RNA heteroduplex oligonucleotide
• SpeakerNatsuki Makiguchi
• Graduate School of Pharmaceutical Science,Tokyo University of Science

Symposium 18

September 28 (Thu.) 9:00-11:00  Room D (10F Conference Room 1001-1&2)

Future perspectives in transporter-driven drug development

• ChairsSumio Ohtsuki
• Department of Pharmaceutical Microbiology, Graduate School of Pharmaceutical Sciences, Kumamoto University
•  Kazuya Maeda
• Laboratory of Pharmaceutics, School of Pharmacy, Kitasato University

• S18-1Approach for the evaluation of transporters of small to medium sized molecules in drug discovery and development
• SpeakerYuji Sakurai
• Research Division, Modality Technology Dept. CHUGAI PHARMACEUTICAL CO., LTD.
• S18-2Endoplasmic reticulum membrane transporter OAT2 regulates hepatic drug metabolism
• SpeakerHiroshi Arakawa
• Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
• S18-3Our efforts for quantitative prediction of OATP1B-mediated clearance and DDIs in a pharmaceutical company
• SpeakerYoshitane Nozaki
• Global DMPK, Eisai Co., Ltd.
• S18-4Role of SLC46A3 in intracellular dynamics of therapeutic modalities involving endocytosis
• SpeakerKatsuhisa Inoue
• Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Symposium 19

September 28 (Thu.) 9:00-11:00  Room E (9F Conference Room 910)

Neonicotinoids and P450; metabolism of neonicotinoids in insects, fungi, vertebrates, and humans

• ChairsSatoshi Yamaori
• Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
•  Hirofumi Ichinose
• Faculty of Agriculture, Kyushu University

• S19-1Cytochrome P450 mediated neonicotinoid resistance in insects
• SpeakerShin'ichi Banba
• Mitsui Chemicals Crop & Life Solutions, Inc. Research & Development Division
• S19-2Identification of cytochrome P450 genes involved in resistance to insecticides in agricultural pests using NGS
• SpeakerAkiya Jouraku
• Institute of Agrobiological Sciences, National Agriculture and Food Research Organization
• S19-3Degradation and detoxification of neonicotinoid insecticides by white-rot fungi
• SpeakerHirofumi Hirai
• Faculty of Faculty of Global Interdisciplinary Science and Innovation, Shizuoka University
• S19-4Species differences in cytochrome P450 and neonicotinoid metabolism
• SpeakerMayumi Ishizuka, Shouta Nakayama, Yoshinori Ikenaka
• Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University

Symposium 20

September 28 (Thu.) 15:00-17:30  Room A (1F Medium Hall - Earth)

Comprehension of the present and future of systems modeling in drug discovery
-Bridging from the traditional model analysis to the latest research-

• ChairKoji Chiba
• Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy

• S20-1Highlight of Modeling & Systems Pharmacology DIS Symposium
• SpeakerTeruki Hamada
• Integrated & Translational Science, Axcelead Drug Discovery Partners, Inc.

• ChairsChie Emoto
• Translational Research Division, Chugai Pharmaceutical Co., Ltd.
•  Tsuyoshi Minematsu
• Immuno-Oncology, Astellas Pharma Inc.

• S20-2The Holy Grail of Patient Characterization: Why, When & How?
• SpeakerAmin Rostami-Hodjegan
• Systems Pharmacology, the University of Manchester; (1) The Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester; (2) Certara USA Inc.

• ChairsHiroyuki Sayama
• Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc.
•  Satoshi Nakayama
• DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation

• S20-3Comprehensive PBPK analyses of coproporphyrin I, an endogenous substrate of hepatic OATP1B, by using a cluster Gauss-Newton method
• SpeakerTakashi Yoshikado
• Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy

• ChairsYoshinobu Nakamaru
• Clinical Pharmacology Strategy, Clinical Development, R&D Japan, Bristol-Myers Squibb K.K.
•  Ryoko Sawamura
• Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd.

• S20-4Application of Physiologically-Based Pharmacokinetic Modeling in Predicting Intestinal P-glycoprotein-Mediated Drug-Drug Interactions
• SpeakerShinji Yamazaki
• PBPK Consultancy, Simcyp Division, Certara USA, Inc.

• ChairsShin'ichi Kijima
• Pharmaceuticals and Medical Devices Agency
•  Yuki Iwaki
• Clinical Pharmacology & Pharmacometrics, Global R&D, Janssen Pharmaceutical K.K.

• S20-5Utilization of physiologically-based pharmacokinetic model to assess disease-mediated therapeutic protein-disease-drug interaction in immune-mediated inflammatory diseases
• SpeakerWangda Zhou
• Clinical pharmacology and Pharmacometrics, Janssen R&D USA

• ChairsKoji Chiba
• Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy
•  Teruki Hamada
• Integrated & Translational Science, Axcelead Drug Discovery Partners, Inc.

• Panel discussion

Symposium 21

September 28 (Thu.) 15:00-18:00  Room B (11F Conference Hall - Winds)

Mechanisms and Dynamics of P450

• ChairsTakehiko Tosha
• Graduate School of Science, University of Hyogo
•  Yuma Morimoto
• Graduate School of Engineering, Nagoya University

• S21-1Regulation of Reactive Intermediates in P450 Catalysis: The Power of Proximal Push
• SpeakerAlec H. Follmer
• University of California, Irvine
• S21-2The Reduction Potentials of P450 Compounds I and II: Insight into the Thermodynamics of C-H Bond Activation
• SpeakerMichael T. Green
• University of California, Irvine
• S21-3QM/MM study of the reaction mechanism of sesamin biosynthesis by cytochrome P450
• SpeakerMitsuo Shoji
• Center for Computational Sciences, University of Tsukuba
• S21-4Key roles of preorganized electric fields in modulating the catalysis of P450s
• SpeakerBinju Wang
• Xiamen University
• S21-5Insights from heme peroxidase intermediates
• SpeakerPeter Moody
• University of Leicester

Symposium 22

September 28 (Thu.) 15:00-17:30  Room D (10F Conference Room 1001-1&2)

New Horizons in Nuclear Receptor Research: Novel Molecular Mechanisms and Beyond

• ChairsToshiyuki Sakaki
• Faculty of Engineering, Toyama prefectural University
•  Masahiko Negishi
• National Institute of Environmental Health Sciences, National Institutes of Health

• S22-1Phosphorylation of Nuclear Receptor; Common Molecular Basis for Activation
• SpeakerRyota Shizu
• University of Shizuoka
• S22-2-1Understanding the molecular mechanisms that cause species differences in CAR-dependent liver cancer promotion
• SpeakersRyota Shizu, Kouichi Yoshinari
  University of Shizuoka
• S22-2-2Human constitutive androstane receptor in hepatocellular carcinoma development
• SpeakerHongbing Wang
• University of Maryland School of Pharmacy
• S22-3Mutation of PXR Phosphorylation Motif at Ser347 is Associated with More Severe Liver Damage in Diet-induced Fatty Liver Disease in Mice
• SpeakerGrace Guo
• Rutgers University
• S22-4Physiological roles of the androgen receptor in male energy metabolism
• SpeakerNaoki Harada
• Osaka Metropolitan University
• S22-5Chemical and structure-guided approaches to selectively modulate the promiscuous pregnane X receptor
• SpeakerTaosheng Chen
• St. Jude children's Research Hospital
• S22-6Elucidation of molecular mechanism of vitamin D and VDR actions using genetically modified rats
• SpeakerToshiyuki Sakaki
• Faculty of Engineering, Toyama prefectural University

Symposium 23

September 28 (Thu.) 15:00-17:30  Room E (9F Conference Room 910)

Basic course of pharmacokinetics on cross-disciplinary

• ChairsSeigo Sanoh
• School of Pharmaceutical Sciences, Wakayama Medical University
•  Tomomi Furihata
• School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

• S23-1Species differences and individual variability in drug metabolism
• SpeakerKaoru Kobayashi
• Meiji Pharmaceutical University
• S23-2Basic consideration of the prediction of in vivo drug pharmacokinetics based on in vitro experiments
• SpeakerKazuya Maeda
• Laboratory of Pharmaceutics, School of Pharmacy, Kitasato University
• S23-3Human iPS cell-derived intestinal cells as an evaluation model of the intestinal absorption process
• SpeakerTakahiro Iwao
• Graduate School of Pharmaceutical Sciences, Nagoya City University
• S23-4Pharmacokinetic research in non-pharmaceutical companies: prediction of pharmacokinetics of food ingredients
• SpeakerShimpei Terasaka
• Safety Science Research, Kao Corporation
• S23-5Role of drug-drug interaction researcher in drug development of Ensitrelvir (Xocova^®) as an oral anti-SARS-CoV-2 Agent
• SpeakerTakanobu Matsuzaki
• Laboratory for Drug Discovery and Development, Shionogi & CO., LTD.

Symposium 24

September 29 (Fri.) 9:00-11:00  Room A (1F Medium Hall - Earth)

Recent trends in MPS development and its applications to drug discovery
-What is happening towards industrial implementation and regulatory acceptance in Japan? -

• ChairsHiroyuki Mizuguchi
• Graduate School of Pharmaceutical Sciences, Osaka University
•  Hideki Hirabayashi
• Takeda Pharmaceutical Company Limited

• S24-1Toward implementation of MPS for drug discovery and development -Challenge and future perspective-
• SpeakerShinji Iwasaki
• Takeda Pharmaceutical Company Limited
• S24-2Utility of Enterocyte-like Cells Differentiated from Human Small Intestinal Tissues
• SpeakerWataru Kishimoto
• Nippon Boehringer Ingelheim Co., Ltd. Dept. Pharmacokinetics and Non-Clinical Safety
• S24-3Current Status of MPS for Regulatory Acceptance
• SpeakerSeiichi Ishida
• Sojo University / National Institute of Health Sciences
• S24-4Contribution of Sumitomo Bakelite to the Drug Discovery through Microphysiological System Technology
• SpeakerTakeshi Sakura
• Marketing & Sales Dept., S-BIO Business Div., Sumitomo Bakelite Co., Ltd.
• S24-5Respiratory MPS utilizing iPSC technology
• SpeakerYuki Yamamoto
• HiLung Inc.
• S24-6Towards Becoming Common Tool; SIEVEWELL^® Development Story
• SpeakerTakashi Osaka
• Tokyo Ohka Kogyo Co., Ltd.

Symposium 25

September 29 (Fri.) 9:00-11:00  Room B (11F Conference Hall - Winds)

P450 Across Plant, Insect, and Microbial Systems

• ChairsHirofumi Ichinose
• Faculty of Agriculture, Kyushu University
•  Masaharu Mizutani
• Graduate School of Agricultural Science, Kobe University
•  Toshiyuki Ohnishi
• Research Institute of Green Science and Technology, Shizuoka University

• S25-1Engineered cytochrome P450 enzymes as catalysts for peptide crosslinking
• SpeakerMax J Cryle
• The Monash Biomedicine Discovery Institute, Monash University
• S25-2Impact of P450s for the Green Transition
• SpeakerBirger Lindberg Møller
• Department of Plant and Environmental Sciences, University of Copenhagen
• S25-3A cytochrome P450 responsible for insecticide resistance in southern house mosquito
• SpeakerKentaro Itokawa
• National Institute of Infectious Diseases
• S25-4The role of cytochrome P450s in the evolution of rhizosphere signaling
• SpeakerHarro J. Bouwmeester
• Swammerdam Institute for Life Sciences, University of Amsterdam
• S25-5Application of fungal cytochrome P450s for production of natural and pseudonatural sesquiterpenoids
• SpeakerHirofumi Ichinose
• Faculty of Agriculture, Kyushu University

Symposium 26

September 29 (Fri.) 9:00-11:00  Room C (6F Reception Hall)

ADMET and AI: What we can do now and what we need to do in the future

• ChairsKouichi Yoshinari
• School of Pharmaceutical Sciences, University of Shizuoka
•  Kenji Mizuguchi
• Institute for Protein Research, Osaka University

• S26-1DruMAP : a Novel Drug Metabolism and Pharmacokinetics Analysis Platform
• SpeakerKenji Mizuguchi
• Institute for Protein Research, Osaka University
• S26-2Computational Investigation in Drug Metabolism and Toxicology
• SpeakerChunzhi Ai
• School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University
• S26-3Challenges to practical ADME problems by machine learning
• SpeakerKoichi Handa
• DMPK Discovery Research Group Toxicology & DMPK Research Department Teijin for Bio-medical Research, TEIJIN PHARMA LIMITED
• S26-4Use of public data for in-house toxicity prediction
• SpeakerYui Migura
• Otsuka Pharmaceutical Co., Ltd.

Symposium 27

September 29 (Fri.) 9:00-11:00  Room D (10F Conference Room 1001-1&2)

Lymphatic and glymphatic system from the perspective of drug development and clinical therapeutics

• ChairsMasanori Tachikawa
• Graduate School of Biomedical Sciences, Tokushima University
•  Yuki Kishino
• Daiichi Sankyo Company, Limited

• S27-1Coordinated roles of glymphatic system and brain barriers
• SpeakerMasanori Tachikawa
• Graduate School of Biomedical Sciences, Tokushima University
• S27-2Lymphatic drug delivery system: treatment strategies for metastatic lymph nodes
• SpeakerTetsuya Kodama
• Graduate School of Biomedical Engineering, Tohoku University
• S27-3The crucial roles of glymphatic system on the pathogenesis of Alzheimer’s disease
• SpeakerKaoru Yamada
• Graduate School of Medicine, University of Tokyo
• S27-4Revisiting Cerebrospinal Fluid Flow in Physiologically Based Pharmacokinetic Model
• SpeakerMakoto Hirasawa
• Daiichi Sankyo Company, Limited
• S27-5Involvement of Cerebrospinal Fluid/Interstitial Fluid Flow in Drug Brain Distribution
• SpeakerSyunsuke Yamamoto
• Takeda Pharmaceutical Company Limited

Symposium 28

September 29 (Fri.) 9:00-11:00  Room E (9F Conference Room 910)

The power of metalloenzymes: Insights from model complexes and beyond

• ChairsHiroshi Fujii
• Department of Chemistry, Biology and Environmental Science
  Nara Women's University
•  Wonwoo Nam
• Ewha Womans University

• S28-1Molecular Mechanism Controlling Formation and Reaction Steps of Compound I
• SpeakerHiroshi Fujii
• Department of Chemistry, Biology and Environmental Science
  Nara Women's University
• S28-2Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation Chemistry
• SpeakerWonwoo Nam
• Ewha Womans University
• S28-3Heme chalcogenates: their distinct differences and similarities in spectroscopic and catalytic properties
• SpeakerTsunehiko Higuchi
• Nagoya City University
• S28-4Reversal of Axial Ligand Effect in the PCET Reactivity of Synthetic Compound-I Analogs
• SpeakerDavid P. Goldberg
• The Johns Hopkins University

Symposium 29

September 29 (Fri.) 13:45-15:45  Room A (1F Medium Hall - Earth)

Rising to the challenge: First-in-human dose determination of new therapeutic modalities

• ChairsSyunsuke Yamamoto
• Takeda Pharmaceutical Company Limited
•  Makiya Nishikawa
• Faculty of Pharmaceutical Sciences, Tokyo University of Science

• S29-1PMDA perspective on estimating the safe starting dose in initial clinical trials for new modalities
• SpeakerKazushige Maki
• Pharmaceuticals and Medical Devices Agency
• S29-2Current status and future perspective of first-in-human dose setting strategy of CAR cell therapy
• SpeakerAkihiko Goto
• Takeda Pharmaceutical Company Limited
• S29-3First-in-Human Starting Dose for Engineered Antibodies
• SpeakerMiho Nagayasu
• Translational Research Division, Chugai Pharmaceutical Co., Ltd.
• S29-4First-in-human dose determination for DS-1501a, an anti-Siglec-15 antibody, by a MABEL approach
• SpeakerTsuyoshi Karibe
• Drug Metabolism & Pharmacokinetics Research Laboratories, DAIICHI SANKYO CO., LTD.

Symposium 30Co-sponsored: "Forecasting Biosynthesis" in the JSPS Grant-in-Aid for Transformative Research Areas (A)

September 29 (Fri.) 13:45-15:45  Room B (11F Conference Hall - Winds)

Oxygenase in natural product biosynthesis

• ChairsOsami Shoji
• Department of Chemistry, Graduate School of Science, Nagoya University
•  Takahiro Mori
• The University of Tokyo

• S30-1Oxidative rearrangements in fungal meroterpenoid biosynthesis
• SpeakerYudai Matsuda
• City University of Hong Kong
• S30-2Structure-function analysis of C-N bond forming P450 enzyme in teleocidin biosynthesis
• SpeakerTakahiro Mori
• The University of Tokyo
• S30-3Analysis P450 reactions involved in natural product biosynthesis in Streptomyces
• SpeakerShunji Takahashi
• RIKEN Center for Sustainable Resource Science
• S30-4Mechanism of nitric oxide reduction by P450 in fungal denitrification
• SpeakerTakehiko Tosha
• Graduate School of Science, University of Hyogo

Symposium 31

September 29 (Fri.) 13:45-15:45  Room C (6F Reception Hall)

Advance Technologies in DMPK Research for Drug Development

• ChairsAkihiro Hisaka
• Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University
•  Takeshi Tajima
• PK Sciences, Translational Medicine, Novartis Pharma K.K.

• S31-1Introduction to the International Consortium for Innovation & Quality in Pharmaceutical Development
• SpeakerNatalie A. Hosea
• Bristol Myers Squibb
• S31-2Hybrid Immunoaffinity LC-MS Bioanalysis and Biotransformation of Biologics
• SpeakerSurinder Kaur
• BioAnalytical Sciences, Genentech / Roche
• S31-3Advancing the science and impact of in silico models for ADME through the IQ Consortium
• SpeakerPrashant Desai
• DMPK, Genentech
• S31-4-1Current practice for QSP model assessment: an IQ consortium survey
• SpeakerKenichi Umehara
• Roche Pharmaceutical Research and Early Development
• S31-4-2Current practice for QSP model assessment: an IQ consortium survey
• SpeakerRyuta Saito
• Mitsubishi Tanabe Pharma Corporation
• S31-5Physiologically Based Biopharmaceutics Modeling in Drug Development
• SpeakerTycho Heimbach
• Pharmaceutical Sciences, Biologics Development and Biopharmaceutics, Merck Research Laboratories，Merck & Co., Inc.

Symposium 32

September 29 (Fri.) 13:45-15:45  Room D (10F Conference Room 1001-1&2)

Application of biomarkers for prediction of drug metabolism and toxicity, and diagnosis

• ChairsSeigo Sanoh
• School of Pharmaceutical Sciences, Wakayama Medical University
•  Toru Usui
• Preclinical Research Unit, Sumitomo Pharma Co., Ltd.

• S32-1Applications and Perspectives of Spatial Transcriptomics to Pharmacokinetic and Biomarker Research
• SpeakerRyousuke Kobayashi
• Axcelead Drug Discovery Partners, Inc.
• S32-2Methodologies and applications of proteomics for biomarker research
• SpeakerSumio Ohtsuki
• Department of Pharmaceutical Microbiology, Graduate School of Pharmaceutical Sciences, Kumamoto University
• S32-3Application of metabolomics on biomarker discovery in adverse drug reactions and psychiatric disorders
• SpeakerKosuke Saito
• Division of Medical Safety Science, National Institute of Health Sciences
• S32-4Advances in mass spectrometry for clinical biomarker discovery
• SpeakerKoretsugu Ogata
• Shimadzu corporation，Analytical＆Measuring Division
• S32-5Can Biomarker be a Trump Card in Translational Drug Discovery Research? or Just for Reassurance
• SpeakerTakafumi Akabane
• Biomarker Discovery & Development Non-Clinical Biomedical Science, Applied Research & Operation, Astellas Pharma Inc.

The predoctoral Researcher-Initiative Session（PRIS）2023

September 27 (Wed.) 13:45-16:15 Room D (10F Conference Room 1001-1&2)

Challenges of next-generation researchers to create knowledge and skills

• ChairsTakumi Sato
• Laboratory of Molecular Toxicology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
•  Yoshiki Hashimoto
• Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo

• PSY-ELInvestigation of the function of UDP-glucuronosyltransferase focusing on its enzymatic features: C-terminal cytoplasmic peptide and oligomer formation
• SpeakerYuu Miyauchi
• Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Sojo University
• PSY-1Comprehensive analyses of DPP-4-mediated linagliptin nonlinear pharmacokinetics in human and rodents by PBPK modeling combined with a cluster Gauss-Newton method
• SpeakerRyo Nakamura
• Laboratory of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Yokohama University of Pharmacy
• PSY-2Evaluation of P-gp-mediated drug-endogenous substrate interactions
• SpeakerHiroki Sunakawa
• Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare
• PSY-3Assessment of biomarkers for SOX therapy dosing in CKD model rats
• SpeakerTakumi Tanaka
• Department of Pharmacokinetics, Graduate school of Kyoto Pharmaceutical University
• PSY-4Preventive effect of omeprazole as drug repositioning strategy on onset of OIPN
• SpeakerYasuhito Tsukushi
• Department of Pharmacokinetics, Graduate school of Kyoto Pharmaceutical University
• PSY-5Establishment of a new and easy-to-construct liver injury mouse model by drinking-water administration
• SpeakerTakumi Iwasaka
• Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
• PSY-6Phosphorylation of neurotrophin receptor TrkB in serum extracellular vesicles as potential biomarker of food component ergothioneine-induced cognitive enhancement in humans
• SpeakerReiya Yamashita
• Laboratory of Molecular Pharmacotherapeutics. Faculty of Pharmacy, Kanazawa University

Selected Oral Presentation 1

Room E　September 27（Wed.）9:00～11:00

• ChairsYuji Ishii
• Department of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University
• Yuu Miyauchi
• Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Sojo University

• SOP1-1Proteomics Reveal In Vivo Effects of Phenobarbital in Mice with Humanized Livers
• SpeakerAlbert Braeuning
• German Federal Institute for Risk Assessment, Dept. Food Safety
• SOP1-2Ligand induced GR heterodimerization with MR and P450 gene regulation
• SpeakerTatsuya Sueyoshi
• Molecular Endocrinology Group, Signal Transduction Laboratory
• SOP1-3Transactivation potencies of estrogen receptor ɑlpha (ERɑ) by DDTs: Interspecies comparison of the killer whale, Baikal seal, and mouse using in vitro and in silico approaches
• SpeakerDave Arthur R. Robledo
• Center for Marine Environmental Studies, Ehime University
• SOP1-4Unraveling potential biomarkers of metabolism associated liver disease and hepatocellular carcinoma
• SpeakerDamjana Rozman
• Centre for Functional Genomics and Bio-Chips, Institute for Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Slovenia
• SOP1-5Generation of liver-on-a-chip for cholestasis research
• SpeakerSayaka Deguchi
• Center for iPS Cell Research and Application (CiRA), Kyoto University
• SOP1-6Investigation of methods for constructing prediction models for CYP inhibition using deep learning
• SpeakerReiko Watanabe
• Institute for Protein Research, Osaka University, Japan／National Institutes of Biomedical Innovation, Health and Nutrition, Japan
• SOP1-7Development of a model for predicting a chemical-induced CYP inhibitory activity using images data showing chemical structure information
• SpeakerTamana Enami
• Regulatory Science, Faculty of Pharmaceutical Sciences, Nagoya City University

Selected Oral Presentation 2

Room E　September 29（Fri.）13:45～15:45

• ChairsJonathan Worrall
• School of Life Sciences, University of Essex
• Shinya Ariyasu
• Department of Chemistry, Graduate School of Science,Nagoya University

• SOP2-1The Discovery of Novel P450-Bioactivated Nematicides
• SpeakerPeter J. Roy
• University of Toronto, CANADA
• SOP2-2Alterations of catalytic mechanisms of atypical cytochromes P450 of the CYP74 clan
• SpeakerSvetlana Gorina
• Kazan Institute of Biochemistry and Biophysics KazSC RAS
• SOP2-3Mechanism of oxidative carbon-carbon bond cleavage by cytochrome P450 2B4
• SpeakerYasuhiro Tateishi
• Vanderbilt University School of Medicine
• SOP2-4Sesamin oxidizing enzyme CYP92B14 regulates lignan accumulation in sesame seeds
• SpeakerErisa Harada
• Suntory Foundation for Life Sciences
• SOP2-5Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes
• SpeakerAlix Charles Harlington
• University of Adelaide